- Content Type
UGC CSIR NET syllabus is defined by the Council of Scientific and Industrial Research (CSIR). CSIR NET Exam 2011 will be conducted twice a year in the month of June and December. Students need to p...
PAPER I: duration: 2 1/2 hours and maximum of 200 marks. 2 marks each question. (25×275×2)
Part -A: 40 General Science questions, attempt any 25 questions.
Part -B: 100 questions, attempt any 75 questions.
PAPER II: 2 1/2 hours duration and shall have a maximum of 200 marks (20×115×12)
This Paper shall consist of 39-45 short answer type questions requiring descriptive answers. Answer each question, on one page.
There shall be one compulsory question of twenty Marks. In addition to the compulsory question, the candidate is required to answer a maximum of 15 questions of twelve marks each.
& THEIR INTERACTION RELAVENT TO
A. Structure of atoms, molecules and chemical bonds.
structure & function of biomolecules (carbohydrates, lipids,
proteins, N.Acids and vitamins).
interactions (Van der Waals, electrostatic, hydrogen bonding,
hydrophobic interaction, etc.).
D. Principles of biophysical chemistry (pH, buffer, reaction kinetics, thermodynamics, colligative properties).
E. Bioenergetics, glycolysis, oxidative phosphorylation, coupled reaction, group transfer, biological energy transducers.
F. Principles of catalysis, enzymes and enzyme kinetics, enzyme regulation, mechanism of enzyme catalysis, isozymes.
G. Conformation of proteins (Ramachandran plot, 20, 30 & 40 structures; domains; motif and folds).
H. Conformation of nucleic acids (A-, B-, Z-, DNA), t-RNA, micro-RNA).
I. Stability of protein and nucleic acid structures.
J. Metabolism of carbohydrates, lipids, amino acids, nucleotides and vitamins.2. CELLULAR ORGANIZATION
A. Membrane structure and function: Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis, ion channels, active transport, ion pumps, mechanism of sorting & regulation of intracellular transport, electrical properties of membranes.
B. Structural organization and function of intracellular organelles: Cell wall, nucleus, mitochondria, Golgi bodies, lysosomes, ER , peroxisomes, plastids, vacuoles, chloroplast, structure & function of cytoskeleton and its role in motility.
C. Organization of genes and chromosomes: Operon, interrupted genes, gene families, structure of chromatin and chromosomes, unique and repetitive DNA, heterochromatin, euchromatin, transposons.
D. Cell division & cell cycle: Mitosis and meiosis, their regulation, steps in cell cycle, and control of cell cycle.
E. Microbial Physiology: Growth, yield & characteristics, strategies of cell division, stress response.3. FUNDAMENTAL PROCESSES
A. DNA replication, repair and recombination: Unit of replication, enzymes involved, replication origin and replication fork, fidelity of replication, extrachromosomal replicons, and DNA damage and repair mechanisms.
B. RNA synthesis and processing: Transcription factors and machinery, formation of initiation complex, transcription activators and repressors, RNA polymerases, capping, elongation & termination, RNA processing, RNA editing, splicing, polyadenylation, structure and function of different types of RNA, RNA transport.
C. Protein synthesis and processing: Ribosome, formation of initiation complex, initiation factors and their regulation, elongation and elongation factors, termination, genetic code, aminoacylation of tRNA, tRNA-identity, aminoacyl tRNA synthetase, translational proof-reading, translational inhibitors, post- translational modification of proteins.
D. Control of gene expression at transcription and translation level: Regulation of phages, viruses, prokaryotic and eukaryotic gene expression, role of chromatin in regulating gene expression and gene silencing.4. CELL COMMUNICATION & CELL SIGNALING
A. Host parasite interaction: Recognition and entry processes of different pathogens like bacteria, viruses into animal and plant host cells, alteration of host cell behavior by pathogens, virus-induced cell transformation, pathogen-induced diseases in animals and plants, cell-cell fusion in both normal and abnormal cells.
B. Cell signaling: Hormones and their receptors, cell surface receptor, signaling through G-protein coupled receptors, signal transduction pathways, second messengers, regulation of signaling pathways, bacterial and plant two-component signaling systems, bacterial chemotaxis and quorum sensing.
C. Cellular communication: Regulation of hema topoiesis, general principles of cell communication, cell adhesion and roles of different adhesion molecules, gap junctions, extracellular matrix, integrins, neurotransmission and its regulation.
D. Cancer: Genetic rearrangements in progenitor cells, oncogenes, tumor suppressor genes, cancer and the cell cycle, virus-induced cancer, metastasis, interaction of cancer cells with normal cells, apoptosis, therapeutic interventions of uncontrolled cell growth.
E. Innate and adaptive immune system: Cells & molecules involved in innate and adaptive immunity, antigens, antigenicity and immunogenicity. B and T cell epitopes, structure & function of antibody molecules, generation of antibody diversity, monoclonal antibodies, antibody engineering, antigen-antibody interactions, MHC molecules, antigen processing & presentation, activation and differentiation of B & T cells, B and T cell receptors, humoral & cell-mediated immune responses, primary & secondary immune modulation, the complement system, Toll-like receptors, cell-mediated effector functions, inflammation, hypersensitivity & autoimmunity, immune response during bacterial (tuberculosis), parasitic (malaria) & viral (HIV) infections, congenital and acquired immunodeficiencies, vaccines.
A. Basic concepts of development: Potency, commitment, specification, induction, competence, determination & differentiation; morphogenetic gradients; cell fate & cell lineages; stem cells; genomic equivalence and the cytoplasmic determinants; imprinting; mutants & transgenics in analysis of development.
B. Gametogenesis, fertilization and early development: Production of gametes, cell surface molecules in sperm-egg recognition in animals; embryo sac development & double fertilization in plants; zygote formation, cleavage, blastula formation, embryonic fields, gastrulation & formation of germ layers in animals; embryogenesis, establishment of symmetry in plants; seed formation & germination.
C. Morphogenesis & organogenesis in animals: Cell aggregation & differentiation in Dictyostelium; axes and pattern formation in Drosophila, amphibia and chick; organogenesis - vulva formation in Caenorhabditis elegans; eye lens induction, limb development & regeneration in vertebrates; differentiation of neurons, post embryonic development-larval formation, metamorphosis; environmental regulation of normal development; sex determination.
D. Morphogenesis and organogenesis in plants: Organization of shoot and root apical meristem; shoot and root development; leaf development and phyllotaxy; transition to flowering, floral meristems and floral development in Arabidopsis and Antirrhinum.
E. Programmed cell death, aging and senescence.6. SYSTEM PHYSIOLOGY - PLANT
A. Photosynthesis: LH complexes; mechanisms of ETC; photoprotective mechanisms; fixation-, CAM pathways.
B. Respiration & photorespiration: TCA cycle; plant mitochondrial ET & ATP synthesis; alternate oxidase; photorespiration.
C. Nitrogen metabolism: Nitrate and ammonium assimilation; amino acid biosynthesis.
D. Plant hormones: Biosynthesis, storage, breakdown and transport; physiological effects and mechanisms of action.
E. Sensory photobiology: Structure, function & mechanisms of action of phytochromes, cryptochromes & phototropins; stomatal movement; photoperiodism and biological clocks.
F. Solute transport & photoassimilate translocation: Uptake, transport & translocation of water, ions, solutes & macromolecules from soil, through cells, across membranes, through xylem & phloem; transpiration; mechanisms of loading & unloading of photoassimilates.
G. Secondary metabolites: Biosynthesis of terpenes, phenols and nitrogenous compounds and their roles.
H. Stress physiology: Responses of plants to biotic (pathogen and insects) and abiotic (water, temperature and salt) stresses; mechanisms of resistance to biotic stress and tolerance to abiotic stress7. SYSTEM PHYSIOLOGY - ANIMAL
A. Blood and circulation: Blood corpuscles, haemopoiesis and formed elements, plasma function, blood volume, blood volume regulation, blood groups, haemoglobin, immunity, haemostasis.
B. Cardiovascular System: Comparative anatomy of heart structure, myogenic heart, specialized tissue, ECG - its principle and significance, cardiac cycle, heart as a pump, blood pressure, neural and chemical regulation of all above.
C. Respiratory system: Comparison of respiration in different species, anatomical considerations, transport of gases, exchange of gases, waste elimination, neural and chemical regulation of respiration.
D. Nervous system: Neurons, action potential, gross neuroanatomy of the brain and spinal cord, central and peripheral nervous system, neural control of muscle tone and posture.
E. Sense organs: Vision, hearing and tactile response.
F. Excretory system: Comparative physiology of excretion, kidney, urine formation, urine concentration, waste elimination, micturition, regulation of water balance, blood volume, blood pressure, electrolyte balance, acid-base balance.
G. Thermoregulation: Comfort zone, body temperature - physical, chemical, neural regulation, acclimatization.
H. Stress and adaptation
I. Digestive system: Digestion, absorption, energy balance, BMR.